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一向自诩“霉运当头”的落魄杀手以“瓢虫”的新代号重操旧业，从老东家处领取了一项运送手提箱的任务。谁料，这次看似“简单”的任务背后却是陷阱重重、险象环生。当瓢虫带着手提箱登上一辆高速列车，顶尖同行们却早已待命、各自为阵，他们的任务之间似乎暗藏巧合与关联，火爆对决一触即发。当疾速列车变成“杀手窝”，活到终点站仅仅是开始。性格迥异、各怀绝技的杀手轮番亮相，对瓢虫展开前后围攻。杀手“柠檬”与瓢虫冤家再相遇唇枪舌战；杀手“蜜柑”对其箱子虎视眈眈，而少女杀手“王子”也与其剑拔弩张。还有来历不明的男子对瓢虫拔刀相向，甚至连乘务员也有着危险的身份，可谓危机四伏。而在这趟旅程的终点，似乎还有一个全球最可怕的杀手组织在等着他们。。Jimmy Connors and his girlfriend want to take part in Paul Whiteman's high school bands contest, but they cannot afford the fare. But per chance they meet Paul Whiteman in person and are able to convince him that their band is good enough, so he lends them the money. But then one of their friends becomes seriously ill and has to be carried to a hospital by plane, and they have ...。一个年轻人开始寻找他素不相识的父亲。。