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莱纳德和谢尔顿是一对室友，他们共同的好友霍华德和拉杰什跟他们一样，是任职于同一所大学的天才科学家，他们都是不折不扣的Geek——智商超群，情商奇低；热爱电玩与漫画，不善与人交流，更不用说与异性相处；他们凡事用科学解决，因此引发不少笑话。美女邻居佩妮的出现，让他们的生活产生了全新的变化。宅男科学家与美女侍应生的碰撞，有了奇妙的化学反应。暗恋佩妮已久的莱纳德终于获得了与她约会的机会，霍华德、拉杰什和谢尔顿帮助他科学分析约会成绩。在科学家们的精确计算下，莱纳德能否抱得美人归？。When Franz presides over the German League, Bismatrck arrives late with a great Dane, a statue of the emperor it urinated on and the claim that his Prussian king should take over the presidency. Franz feels that's a。Klara is going to die today unless she kills her husband instead. The Calendar Killer has given her that impossible choice. When Jules starts his night shift at a safety helpline for lonely women on their way home Klara's call reaches him.。